Natalie Tran has 229 videos available on her YouTube channel and is the most-subscribed of all-time in Australia, She is also the number one most-subscribed for the categories of Director and Partners for Australia, and manages the 38th-most viewed channel on YouTube of all time. She was the first runner up in the Miss YouTube contest created by Michael Buckley of What The Buck. Tran vlogs about her daily-life situations as a university student.

Her videos include observational and self-deprecating humour, as well as stream-of-consciousness commentary on social dilemmas, such as how much money to spend on gifts for friends and appropriate telephone etiquette. Other videos include multi-role skits, where (with occasional exceptions) Tran plays most roles, combining multiple takes using split-screen compositing.